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NOVEMBER 25, 2021
One experimental test can detect 50 different cancers.
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Every year, thousands of Americans undergo routine screening to catch cancer in its early stages, while it’s still treatable. But these routine tests can be painful and invasive, and doctors only regularly screen for five of some of the most common types of cancer.
So for decades, scientists have been working on ways to screen for cancers using a simple blood draw rather than a painful biopsy or invasive test. These so-called “blood biopsy” tests are closer than ever to dramatically improving the way doctors screen for cancer.
Galleri, a new blood test by health care company GRAIL, is one of the most advanced blood biopsy tests. It works by looking for fragments of DNA in a person’s blood that indicate the presence of more than 50 types of cancer.
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According to Dr. Pashtoon Kasi, director of colon cancer research and precision medicine at Weill Cornell Medicine, the underlying technology was actually first used to serve a different purpose.
“The same technology has been around for more than 20 years,” he said. “It started with prenatal diagnostics.”
But now, similar technology has been harnessed to detect early signatures of cancer.
Dr. Michael Seiden, the former president of the US Oncology Network, sees blood biopsy tests as part of the future wave of so-called “precision medicine” — the idea that each person’s medical care can be tailored to fit their specific genetics, medical needs and unique characteristics.
Precision medicine tries “to learn as much [as possible] about a person’s health through sort of sophisticated diagnostic tests,” Seiden said.
According to Kasi, less than two thirds of Americans get screened for colon cancer, which often involves an invasive procedure called a colonoscopy. A simple blood biopsy such as Galleri may improve current cancer screening due to ease of use, he said.
But despite the recent advancements, many doctors say there’s a long way to go — and some say there are reasons to wait for more research to be done.
The Galleri test, though promising, is not yet FDA approved. It still needs to undergo more testing to show it can produce reliable results every time.
“What you want to see is evidence it detects cancers early and in a reasonably good-sized population and that there aren’t harms done,” Dr. Ann Partridge, a breast oncologist at the Dana-Farber Cancer Institute, said.
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But there’s another, more complex challenge, some experts say. In routine medical care, more testing isn’t always better.
“To do a screening test for any kind of disease or disorder, you have to consider what’s the benefit of doing it,” Partridge said. “If you live for 15 minutes longer, it might not be worth it. But if you live for 10 months longer, it might be worth it.”
A common refrain in cancer treatment is “earlier is better”: that the earlier a cancer can be found, the treatment is often more successful. However, sometimes it can be difficult to tell the difference between an early cancer and a non-cancerous growth.
A final diagnosis often involves an invasive procedure, such as a needle biopsy or surgery in order to remove tissue. These procedures are not without risk, and any screening tool, such as the Galleri test, should reduce the number of unnecessary procedures by not flagging non-cancers as cancers.
